I'm with Tommy on this one!
I honestly don't know what you are on about DS. Even if you sequence with audio samples, you are still going to have to record the audio in the first place. Without sequencing in midi first, you will have to play everypart live! If you are making dark slow ambient music this may not be a problem, but if you are making faster tempo dance (like many other people seem to be) then you will be better off to sequence before recording the audio (specially the drums - unless using loops).
I think the loop based mixing culture has caused a midi ignorance.
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