I personally don't have any experience with the ADI line but, in general, the rme lines have a very good reputation. I have been thinking about replacing my layla 24 (to go with a firewire solution) and the fireface 800, hands down, comes out on top. It's an expensive beast, but really seems to outshine all other competitors in it's class. I think the adi line is highly touted as well.
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