For the serious answer...
Virus + Rock band???? Odd combination - virus isnt exactly the first synth comes to mind for that scenario. V-synth is good - its guitar patches sound more convincing than most guitarists and can certainly out-scream them
If its a Virus TI - then Mono Sync leads, Use Ring mod as well, be gentle with the subosc and detune. Also definately worth trying wavetable sine with freqmod or phasemod FM. Crank the ring mod - as well as hardening the timbre, his can add loads of bite and energy to presence range. Use unison and start phase sync to add more bite/energy if needed.
If you want an overdriven sound, then rectifier or wave shaper distortion maybe modulaed by key on velocity to give it an overdrive rather than just fuzz feel. Bit reduction is good for making it scream as well.
Also try a bit of resonance to filter 1, use >64 osc volume, a bit of saturation followed by a bandpass filter to really focus the thickened sound. If you want to use reso allmost as a 4th osc, then set cutoff keyfollow to max.
Careful using distortion though, it may spread the sound energy too much so it doesnt cut through anymore.
A quick starter for a dirty organ-like lead (theoretical as I'm at work atm so cant try it):
Select init patch, Osc 1 - wavetable, sine, Osc 2, wave table sine, Start phase at about 50-60%, punch to max, unison to 2 and a bit of detune. Ring mod to about 90%, FM to freqmod, FM level 0-10% range, Osc 2 detune +12 semi.
Erm, filer 1, rectifier sat type, osc volume at around 75%, filter 2 bandpass, cutoff follow, reso at arond 25%, bit of env mod - not to much. Leave the filter and amp envs where they are for now. That should come out a bit like a softly overdriven hammond with alot of presence energy. Use LFO3 to mod the osc pitch if you want it more rock organ like.
In the matrix, map velocity to osc volume at about +20, drop ring mod to 50%, and map velocity to also mod the ring mod by about +30 or so. End result should snarl a bit more when you nail it. crank the FM up a tiny bit to bring in some higher harmonics. For a harder attack, env mod the FM a tiny bit.
For FX - chorus, phaser will generally sap energy, but extreme settings of either can add alot of energy.