The only times I have seen the virus used live is at electronic shows. My guess is that the people who use the virus live usually use it as a self contained unit - eg, the virus constitutes the main part of the song that is being played. This is typically electronic style music. Whereas when you have a full band playing (drums, bass, guitar, vox) the synth sound is typically complimentary - strings, pads, piano etc., which people usually choose one of the big three for.
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