You cannot change a samples as you would. Since they cannot "load" into the virus, you cannot effect it's frequency/pitch/FM/RM... You can however use the inputs and route the sound through the filters which can be modulated by whatever the heck you want. Then apply some effects for a more interesting result.
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SH- 101, BassStation, Alesis Andromeda, Novation Nova, Virus TI 3.0.3 , ATC-1, Waldorf Blofeld... Lexicon, Line 6, Boss.... 96 Point Patchbay 
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