As a counter comment to Berns, I run on Cubase 6 on Win7 and previously C5 on an XP machine. Havent had crackles or pops since OS 4 was released, the only sync issues I have now are with arp clocks messing up randomly at times, which can be very frustrating (they tend to go out, and then come back in, requires you to hit play a few times). I definitely dont need a PCI/USB card, I replaced the original USB cable and since then have had no issues...
VC software actually runs really well for me. I would buy it with a refund policy and give it a solid work over if you are concerned with those issues.
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