Yep, but in my case it's better to send midi to a synthesizer from the sound card, instead of the keyboard, which is a novation sl mk2. Don't know why, but the timing is better that way. And some sound cards, like RME, have a rock solid world clock which is very reliable.
Don't know about software integration on synths, since I don't own the TI but the C instead. But it's kind of natural, I guess. What you change on software has to be sent some way or another to the hardware to update the patch, so a little lag feels natural to me.
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