maybe your host is sending some cc messages that conflict with the transposing thing?
have you tried to use it stand alone? to see if this still happens? I know some people have issues with Logic and Ableton, they do send some kind of message to your hardware devices (maybe to keep them in sync), but some people experience odd behaviour because of that and there's even people who place some midi filter to block those messages in the host, so they don't reach the machines. try that and I'd contact Access right away, bet they've heard of it before and can point you in the right direction...
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