The main difference, as far as sound design is concerned, is that with a super saw like oscillator, you're generating the voices at the oscillator level, while unison duplicates the entire signal, filters and everything included - so it kind of replicates the whole signal, as you would with a multi-patch with the same single replicated with a maximum of 16 parts (on the Virus, no wonder). It sounds different, and for much classic super saw sounds the oscillator simply nukes unison out of the water. For a warm analogue-like kind of pad, for example, then unison would be better, not wacky out of this world settings, just a couple of voices slightly detuned would do the job nice and easy.
The Virus has an almost perfect emulation of the JP 8000/8080 oscillator, sounding almost identical to its older counterpart - there's videos online with such comparisons. Maybe it will benefit from a slight EQ (internal one would do fine), the broad stroke high shelf making the highs a bit more "in your face" - at least that used to be the case up until the Virus C.
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