If Virus compatibility is important to you, be sure to stick with the list of officially supported ones from Access. Over the years it seems users of this forum have had the best luck with Cubase and Virus compatibility. Other DAWs have their strengths too but when it comes to plug-in compatibility, Steinberg products are the gold standard by which others must follow.
Since you already have some familiarity with Cubase I think your choice is easy. Don't limit yourself to built-in instruments of the DAW. The ones that come with Cubase are quite good but third party plug-ins are often a lot better. Do the $10 upgrade from Padshop (built in) to Padshop Pro, that's a great instrument.
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