Hey there mate, I run Cubase flawlessly with the Virus TI. In terms of workflow, I really think it's between Logic, Cubase and Ableton Live (Sonar for me, is very badly designed).
If I had a Mac, I'd be going for Logic (traditional DAW) OR Live (more cutting edge but less features)
If I had a PC, I'd be going for Cubase (traditional DAW) OR Live (more cutting edge but less features)
However, I can only vouch for the Virus TI in Cubase personally
Good luck
Fots