My brief experience with the TI2 was that the disappearance of sound described in the OP would more likely be caused by DSP limitations, i.e. could happen on a multi-patch or even on complex singles depending on how many system resources being used. The USB throughput could be limiting too, but I think the symptoms would be different if that's the case (latency issues rather than loss of individual sounds).
durr : are you sure this is a USB issue? If you set up the 6 synths, and just play the Virus through headphones is the problem still present?
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