If you want the virus ti for the ti bit, I have to disappoint you. there are many users having problems with it, for example hanging notes, "drunk" arps and no accurate timing. there are many users here in this forum and in the mailing list using the virus as an ordinary hardware synths, so with MIDI and audio cables.
There are some synthesizers introduced by Roland with a total integration. The virus TI only supports 16 bit audio via USB, so if you do post processing etc. that IS not enough. I don't know whether Roland supports 16 bits as well though...
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