Hey Chicago thanks for the reply,
Contacted Virus Support and after a few emails where I did the same restarts and uninstallations with no luck, the advice was to change the USB cable over and test it. Before I did the swap I did one last un/reinstall with NO usb connections (including mouse), to be safe, and still couldnt get it to work.
Swapped the cable from my Tascam US144 into the Virus and voila. Cubase 5 instadetected it, Virus Control Center worked perfectly, and the USB detections and MIDI sends are now working. Bit of a novice move on my part not to try another cable beforehand, but since it was working before the OS install I didnt think it would be be the culprit.
Quick comment to say; the Virus Support staff are VERY quick to respond and extremely polite and professional. Could not have been happier with the communication standard.
And now I can start playing with Cubase 5 and OS 3!
