I run my virus through Spdif (fully digital connection) into a motu ultralite, and process some gear through it, usually my waldorf pulse or XT.
I would run it straight through the USB but I don't really ever use viruscontrol.
I find that processing the gear through the virus and then through spdif is much better quality than going through the ultralite's conversion.
I imagine it would be the same if you were using the virus through USB.
I've wondered for a while just how good the converters in the virus TI's really are.
as for leaving it on, I'm sure it wouldn't be bad, but I know I get uncomfortable leaving my gear on if it isnt being used.
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