To make Calyx style sounds you can't do it all inside the virus. A lot of post processing is happening there, even though the original sounds might come from a virus. I know that he uses a pod distortion unit - the XT version looks cool if you can afford it. he also loads the recorded audio into his emu ultra and uses its filters to mangle the sound.
A good reese can be made in the virus - you need to detune several sawtooth waves, apply a low pass filter and add some chorus / phasing / distortion to suit. The unison setting can help too. A good method might be to make several patches, then get into multimode and run them all from the same midi channel - I don't like multimode though so i don't usually get that far.